| |
 |
|
Lactate Dehydrogenase (LDH) is a ubiquitously-expressed intracellular enzyme which catalyzes the reversible oxidation of lactate to pyruvate. LDH is one of the most clinically important protein markers in serum because its level changes in response to a number of health-related states. For example, elevated LDH serum levels are often caused by heart, liver and kidney disease as well as in numerous types of cancer. Also, the presence of elevated levels of the enzyme in serum after administration of drugs and experimental therapeutic agents is associated with organ toxicity. Therefore, monitoring serum levels of LDH enzyme has become a routine and fundamental means to monitor organ toxicity.
The MaxDiscovery™ Lactate Dehydrogenase (LDH) Enzymatic Assay Kit is a colorimetric plate-based assay to directly determine the amount of Lactate Dehydrogenase enzyme in samples. This kit enables biomedical researchers to determine LDH levels in serum from rodents, such as mice and rats, and other vertebrates including fish. The assay utilizes a simple, proven colorimetric (UV) enzymatic assay to specifically detect LDH. It provides accurate results even in complex liquid mixtures.
Selected References:
Roubille, F., et al. (2011) Delayed Postconditioning in the Mouse Heart In Vivo. Circulation, 124: 1330-1336. |
|
 |
|
|