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For targeted delivery of siRNA
Mehta, G., Scheinman, R. I., Holers, V. M. and Banda, N. K. (2015) A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. Journal of Immunology. doi: 10.4049/jimmunol.1403012.
If you are planning on storing the kit for >1 month, we recommend storing the T3 Carrier in a -20ºC, frost-free freezer. The shelf life of the T3-Max Conjugation Kit is 6 months when stored properly.
This kit is sufficient for 15 - 20 injections. The number of in vivo injections will vary depending on specificity of the user’s antibody, concentration of siRNA and target receptor population. Concentration optimization should be performed before each experiment.
Each kit can conjugate up to 3 mg of antibody
Each kit provides the reagents to make:
3 mg of one antibody conjugate, or
1 mg each of three different antibody conjugates, or
2 mg of one antibody conjugate and 1 mg of two other antibody conjugates