Directed In Vivo Delivery Agents

To assist in the directed delivery of siRNA molecules into animals, BIOO Scientific offers antibodies conjugated to Protamine Sulfate.  Protamine Sulfate is a small, positively charged, arginine rich protein which is traditionally used to reverse the anticoagulant effects of heparin by binding to it.  It has been found that Protamine Sulfate can also associate with nucleic acids such as siRNA and miRNA molecules. For this reason Protamine Sulfate conjugated antibodies have significant potential to be used with siRNA for the directed delivery of siRNA and miRNA molecules into animal tissues via cell surface receptors.

To generate siRNA or miRNA bound to Protamine Sulfate conjugated antibody, simply mix the siRNA or miRNA with the conjugated antibody in the antibody storage buffer and incubate at 30°C for 15 minutes. Following the incubation the RNA/antibody complex can be diluted into a sterile saline solution and injected directly into the animal.

*Custom antibody-protamine conjugates are available upon request*

If the antibody you are interested in evaluating for directed in vivo delivery is not listed we can generate monoclonal antibody against the target of interest in 5 weeks provided that the antigen is supplied to us.

For additional information on BIOO MaxSuppressor™ Directed In Vivo Delivery Agents, please contact BIOO Technical Services Department at techsupport3@biooscientific.com or call (512) 707-0921.

 
MaxSuppressor™ products are intended for laboratory use only, unless otherwise indicated. They are NOT for clinical diagnostic use. MaxSuppressor and MaxSignal are Trademarks of Bioo Scientific Corporation (BIOO).