Catalog #: 3603
VEGFR2 (KDR) Antibody Conjugated to Protamine

The vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) pathway regulates proliferation, survival, and permeability of vasculature. One important pathway regulating angiogenic events is VEGF acting through two receptors: VEGF receptor 1 (VEGFR-1) and VEGFR-2. It is thought that VEGF-dependent activation of VEGFR-2 is involved in mediating endothelial cell proliferation, survival, and vascular permeability, whereas VEGFR-1 might play an inhibitory role by sequestering VEGF, and thus preventing its interaction with VEGFR-2. The VEGF/VEGFR-2 pathway is active in angiogenesis, as evidenced by the fact that substances inactivating VEGF or the VEGFR-2 interfere with blood vessel proliferation.

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